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Have had withdrawal symptoms if you missed a dose. Antidepressant Escitalopram (Lexapro); Sertraline (Zoloft). With a low risk of If you’ve just realized that you missed your medication, take it as soon as you remember. However, if you’re nearing your next dose, don’t Dosage for Lexapro Major Depressive Disorder Adults. The recommended dosage of Lexapro in adults is 10 mg once daily. A fixed-dose trial of Lexapro demonstrated the effectiveness of both 10 mg and 20 mg of Lexapro, but failed to demonstrate a greater benefit of 20 mg over 10 mg [see Clinical Studies]. However, elderly patients are more likely to have hyponatremia (low sodium in the blood) and age-related liver problems,