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by AD Halli-Tierney 2024 Cited by 45First-line therapy for motor symptom management in Parkinson disease is carbidopa/levodopa because of its effectiveness in managing tremors treatment. Parkinson’s Drug- Possible Improvements in Motor Skills and Tremors. 4.1K views 1 year ago more. Zhittya Genesis Medicine. 3.18K. Propranolol, a drug used for hypertension, heart disease, and migraine headaches, is occasionally helpful for managing parkinsonian tremors, as is Clozapine, a Parkinsonian tremor is common and one of the first signs of Parkinson’s disease, although not all people with Parkinson’s disease have tremor. Its shaking is most noticeable when the hands are at rest and may look as if someone’s trying to roll a pill between the thumb and a finger.