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Which drugs cause similar effects? Drugs causing similar effects as morphine include: Opium, codeine, heroin, methadone, hydrocodone, fentanyl, and oxycodone What is its legal status in the United States? Morphine is a Schedule II narcotic under the Controlled Substances Act. Morphine Morphine www.getsmartaboutdrugs.com October 2024 A full opioid agonist, is relatively selective for the mu receptor, although it can interact with other opioid receptors at higher doses. The clinical significance of these findings is unknown. ADVERSE REACTIONS. Adverse Drug Reaction Overview. Adverse effects of morphine sulfate Dr. Daniel Lopez-Tan from Legacy Hospice shared that the idea that morphine speeds up death could have arisen because the opioid is commonly associated with end-of-life care.