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Types of drugs that can interact with lorazepam oral tablets include: Opioids. Taking lorazepam oral tablets with opioids can increase the risk of certain serious side effects, coma, and death Use WebMD s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Lorazepam, The risk or severity of CNS depression can be increased when Lorazepam is combined with Topiramate. Lorcaserin, The risk or severity of CNS by CM Barkley 2024 Cited by 12Topiramate (TPM) and lorazepam (LZP) are two examples of frequently-prescribed medications that are associated with a high incidence of cognitive impairment.