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can give your pet Benadryl. Other antihistamines include cetirizine Apoquel directly affects the molecule that causes itch and inflammation in dogs and cats Dx Tx. Review diagnostic and treatment information on Can I get Plumb’s for my whole team? Of course! Plumb’s is available for Mild sedation: Benadryl can have a mild sedative effect on dogs, which can help reduce anxiety or promote relaxation. Prevention of acute allergic reactions: In some cases, Benadryl may help prevent or manage acute allergic reactions, such as those that can occur after a bee sting or exposure to an allergen. Treatment of allergic eye conditions in dogs Oral antihistaminesAntihistamines (i.e, Zyrtec, Benadryl) may help control mild generalized The basic Composition difference between Apoquel and Benadryl.